This is to remind you of the TODAY's Physics Colloquium:
Speaker: Hermann E. Gaub, Applied Physics and Center for Nanoscience,
University Munich D
Date: Wednesday, November 26, 2003
Time: 16:45 h (coffee at 16:15 h in front of auditorium)
Place: ETH Hönggerberg, HPV G4
Title: Single Molecule Force Spectroscopy:
A Better Understanding of Bio-Molecules with Newton?
Abstract:
Local interactions between bio-molecules regulate the complex diversity
of life. With the developement of AFM-based techniques, which allow
control and measurement of interaction forces between individual
molecules at physiological conditions, a multitude of essential
processes such as molecular recognition and protein folding have become
accessible at unparalleled resolution and sensitivity. Moreover, the
description of molecular devices and machines based on forces rather
than thermodynamic variables has provided novel insight into their
biological function:
Newton revisited! This lecture will highlight the advances of the recent
years.
For further reading:
Friedsam, Wehle, Kühner and Gaub,
"Dynamic single-molecule force spectroscopy: bond rupture analysis with
variable spacer length"
J. Phys.: Condens. Matter (2003),Vol 15 , p 1709-
Albrecht, Blank, Lalic-Multhaler, Bayer, H. Clausen-Schaumann and Gaub,
"DNA: a programmable force sensor"
Science (2003),Vol 301, p 367-
Hugel, Holland, Cattani, Moroder, Seitz and Gaub,
"Single-Molecule Optomechanical Cycle"
Science (2002),Vol 296, p 1103